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Thermal Imaging Method for Evaluation of Rheumatoid Arthritis in Small Animal Model – A Preliminary Study

U. Snekhalatha, M. Anburajan, B. Venkatraman, M. Menaka, Baldev Raj

Abstract


Thermal imaging method is a non invasive, non contact, accurate method for detecting the inflammation in arthritis compared to other diagnostic methods. Thermal imaging plays a crucial role in evaluation and monitoring the inflammation in rheumatoid arthritis .The aim of our study was to evaluate and monitor the inflammatory arthritis in rats by means of skin temperature measurement using thermal imaging technique. 0.2ml of mixture of freunds complete adjuvant mixed with a phosphate buffer saline at 1:1 are injected in right hind limb and forelimb and left limbs are kept for control. Thermal analysis of wistar rats showed that significant increase in mean temperature difference about 0.80c and 0.90c increase in temperature in inflamed right fore limb and hind limb than the left limb controls.

Keywords


Rheumatoid Arthritis, Freunds Complete Adjuvant Skin Temperature Measurement, Thermal Imaging, Wistar Rat.

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References


http://www.medicinenet.com/rheumatoid_arthritis/article.htm Accessed 26th june 2011.

Vingsbo .C,Sahistrand.P,Johan.G.Brun,Jonsson.R,Saxne.T,Homdahl.R. “Pristane Induced Arthritis in rats :A new model of rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non major histocomaptibility complex genes.” American Journal of pathology 1996;vol.149 No .5.pp1675-1682.

Bendele A M. “Animal Model of Rheumatoid arthritis”.J Musculoskel Neuron Interact 2001; 1(4):377-385.

Gierer P,Ibrahim S,Mittlmeier T,Koczan D,Moeller S,Landes J etal “Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis”.Arthritis Res Ther 2005, 7:R868-876

Shou J, Bull CM, Li L, Qian HR, Wei T, Luo S, Perkins D, Solenberg PJ, Tan SL, Chen XY, Roehm NW, Wolos JA, Onyia JE: “Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model”. Arthritis Res Ther 2006, 8:R28-42

Snekhalatha.U, Anburajan.M “Study of Rheumatoid arthritis using Thermography in small Animal model.” Proceedings of International Conference on Advances in Engineering and Technology, (ICAET-2011) ,2011 ISBN: 978-1-4507-6433-9

Van de Berg WB, Joosten LAB, Helsen MMA, van de Loo FAJ, “Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment,” Clin Exp Immunol, ,vol 95,pp 237–243.1994.

David E.Trentham,W.Joseph Mccune,Pia Susman,John R.David., “Autoimmunity to collagen in Adjuvant Arthritis of rats”.J.Clin Invest,vol 66,1980,pp 1109-1117

Pearson C.M. “Developement of Arthritis ,periarthritis in rats given adjuvant..” Proc soc.Exp.Biol.Med 1956;.91:95-101

Corvo, ML, Jorge JCS, Hof RV, Curz, MEM, Crommelin DJA, Storm G, “Superoxide dismutase entrappedin long-circulating liposomes: formulation design and therapeutic activity in rat adjuvant arthritis”,Biochimica et Biophysica Acta,, vol 1564, pp 227–236.2000

Brenner M,Braun C,Oster M,Gulko P S. “Thermal signature nalysis as a novel method of evaluating inflammatory arthtrtis activity”. Ann Rheum Dis. 2006 March; 65(3): 306–311

Brian M. Sanchez, Mark Lesch David Bramme, , Susan E. BoveMelissa Thiel and Kenneth S. “Use of portable thermal imagingr unit asa rapid,quantitative method of evaluating inflammation and experimental arthritis.Journal of pharmacological and Toxological methods” ,2008;vol57(3): pp169-175.


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